Abstract
Abstract The in vitro efficacy of the modified Skeggs-Leonards dialyzer in dialysis of methanol, ethanol, diethyl- and allyl-isopropylbarbituric acid, and bromide has been examined. The experimental results are compared to our clinical results previously published. The in vitro efficacy of the Skeggs-Leonards dialyzer in dialysis of the toxic compounds studied was found to be comparable to in vivo dialyzability of the same substances. From analysis of the clinical results obtained by treatment of poisonings with the above-mentioned toxic substances, it is concluded that important disequilibrium between intra-and extracellular fluid compartments is not induced by efficacious hemodialysis. Besides providing data for comparison of the efficacy of various dialyzers, studies of in vitro dialyzability seem valuable for the evaluation of indications of hemodialysis in treatment of acute poisonings.
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