Abstract
Abstract Alpha thalassemia, one of the most common monogenicdisorders in the world, results from an imbalance in α-globin chainsynthesis, being the -α 3.7 deletion the most important. Togetherwith beta thalassemia and iron deficiency, alpha thalassemiarepresents an important cause of microcytosis and hypochromia.In order to diagnose and evaluate the prevalence of alpha-thalassemia (- α 3.7 deletion) in individuals with microcytosis and/or hypochromia (MCV ≤ 82 fL and MCH ≤ 27 pg, respectively)were analyzed blood samples from 319 individuals referred tohematology outpatient clinic of Hemocentro Dalton BarbosaCunha, Natal-RN. All peripheral blood samples were submittedto the following laboratorial analysis: erythrogram, hemoglobinelectrophoresis on cellulose acetate strips at alkaline pH,measurement of hemoglobins A 2 and Fetal and serum ferritin bychemiluminescent immunometric assay. DNA samples wereextracted by commercial kit and the - α 3.7 deletion was investigatedby PCR. Among the 319 subjects studied, 105 (32,9%) presentedα-thalassemia: 93 (29,1%) were heterozygous (-α
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