Abstract
Chlamydophila pneumoniae is nadotrophic to endothelial, smooth muscle cells of blood vessels. Proven ability of the pathogen to initiate atherosclerosis and exacerbate it. The incidence of acute C. pneumoniae infection is higher in patients with acute coronary syndrome than in patients with chronic ischemic heart disease according to the published papers. The aim of the research was the diagnostics of C. pneumoniae infection in patients with acute coronary syndrome by two methods based on different principles. A total of 20 patients admitted to hospital with a preliminary acute coronary syndrome diagnosis. During the first hospital hours of stay based on complaints, medical history, physical examination, results of laboratory and instrumental examination those patients were diagnosed as unstable angina (n = 10) or nontransmural myocardial infarction (n = 10). According to treatment standart all patients underwent coronary angiography and angioplasty. Furthermore, these patients fulfilled fence of the clinical material as mucosal scrapings nasal passages and posterior wall of the oropharynx applied on glass slides. Also, there were samples of arterial blood smears, obtained from the conductors installed in the locations pointed to implement the coronary arteries and angioplasty. These samples were examined by indirect immunofluorescence with the form of specific monoclonal antibodies against the cell wall major outer membrane protein of C. pneumoniae. Serum was used for immunoassay to quantify classes A and G immunoglobulins against C. pneumoniae. When comparing the results of two diagnostics methods of C. pneumoniae chronic infection, it was diagnosed in 5 of the 20 patients studied. One patient was with unstable angina and 4 were with nontransmural myocardial infarction. The presence of acute infection C. pneumoniae has been proven in 9 of 20 patients, including 4 patients with unstable angina and 5 with nontransmural myocardial infarction. Also found that patients with acute coronary syndrome, the infection can occur both by seropositive and seronegative types. Thus, acute coronary syndrome may be associated with chronic or acute infection of C. pneumoniae. The relevance of further study of the infection in patients with atherosclerosis was confirmed once again.
Highlights
С точки зрения хламидофильной гипотезы атеросклероза, атеросклеротической бляшки (АБ) является ничем иным, как вторичным сосудистым очагом инфекции C. pneumoniae, который развивается вследствие гематогенной диссеминации возбудителя из локализованных на слизистых оболочках дыхательных путей первичных очагов [7]
Chlamydophila pneumoniae is nadotrophic to endothelial, smooth muscle cells of blood vessels
exacerbate it. The incidence of acute C. pneumoniae infection is higher in patients with acute coronary syndrome
Summary
ОСОБЕННОСТИ ДИАГНОСТИКИ ИНФЕКЦИИ, ВЫЗВАННОЙ CHLAMYDOPHILA PNEUMONIAE, У БОЛЬНЫХ ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ. Частота острой инфекции C. pneumoniae выше у больных острым коронарным синдромом, нежели у пациентов с хронической ишемической болезнью сердца. Целью работы стала диагностика инфекции C. pneumoniae у больных острым коронарным синдромом двумя методами, основанными на разных принципах. При сопоставлении результатов двух основанных на разных принципах методов диагностики хроническая инфекция C. pneumoniae была диагностирована у 5 из 20 обследованных пациентов. Наличие острой инфекции C. pneumoniae было доказано у 9 из 20 пациентов, из них 4 пациента с нестабильной стенокардией и 5 — с нетрансмуральным инфарктом миокарда. Ключевые слова: нестабильная стенокардия, нетрансмуральный инфаркт миокарда, инфекция Chlamydophila pneumoniae, диагностика, непрямая иммунофлюоресценция, иммуноферментный анализ. Особенности диагностики инфекции, вызванной Chlamydophila pneumoniae, у больных острым коронарным синдромом // Инфекция и иммунитет.
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