Diagnostics and treatment of urticarial vasculitis associated with COVID-19

Abstract

Currently, the problem of COVID-19 continues. The possible consequences of acute infection are not entirely clear. Various dermatological manifestations of COVID-19, including urticarial vasculitis (UV), are increasingly being reported. Urticarial vasculitis (UV) is a rare chronic inflammatory disease presenting with long-lasting wheals with or without angioedema [1]. Histopathological, UV is a leukocytoclastic vasculitis, a common form of small vessel vasculitis, including arterioles, capillaries, and postcapillary venules, in which the inflammatory infiltrate consists of neutrophils with fibrinoid necrosis and nuclear disintegration into fragments (“leukocytoclasia”) [1]. We report a case of urticular vasculitis in a 54-year-old woman who does not suffer from systemic diseases, with a burdened allergic anamnesis (drug allergy to levomycetin with a clinic of widespread toxicoderma). For 2 months after discharge, the patient took colchicine at a dosage of 0.5 mg, 1 tablet 2 times a day, which reduced the manifestation of clinical symptoms and achieved remission. According to the results of a comprehensive examination, a previously transferred COVID-19 infection is considered as a likely etiological factor.