Abstract
The article is devoted to the problem of kidney stones. The authors provide the results of a study of 107 men aged 48 to 76 years, were divided into three groups – primary and two control groups. The main and the first control group consisted of 40 patients with recurrent urolithiasis without urinary tract obstruction after endoscopic stone removal and partial androgen deficiency. The second control group consisted of 27 healthy men aged 48 to 70 years. Patients for one year he was promoted endoscopic removal of urinary stones: transurethral nephrolithotripsy – 55 patients, and percutaneous nephrolithotripsy – 25. After discharge from hospital all patients had a diagnosis and correction of metabolic disorders using physical-chemical and biochemical indicators of urine and blood. To study the mineral composition and structural-textural features of urinary stones and their fragments after surgical interventions were performed: x-ray diffraction, infrared spectroscopy, polarization and electron microscopy. Was carried out following the relapse of urolithiasis: patients of the main group received pathogenetic androgen therapy as monotherapy, and patients in the control group conventional treatment (antibiotics, spasmolytic, herbal remedies). The results of therapy and follow-up care for 6 years showed a low recurrence of stone formation in patients of the main group and highest in the control. Age-related decline in androgen levels in men may be an additional factor in stone formation. Pathogenic androgen replacement therapy leads to normalization of the content of lithogenic substances in the blood and urine, as well as physico-chemical properties of urine, thereby reducing the process of stone formation.
Highlights
Diagnostics and correction of metabolic disorders in patients with recurrent urolithiasis after endoscopic removal of stones
The article is devoted to the problem of kidney stones
The authors provide the results of a study of 107 men aged 48 to 76 years, were divided into three groups – primary and two control groups
Summary
В течение 1 года произведено эндоскопическое удаление мочевых камней: трансуретральная нефролитотрипсия – 55 пациентам, а перкутанная нефролитотрипсия – 25. Результаты терапии и диспансерного наблюдения в течение 6 лет показали низкую частоту рецидива камнеобразования в основной группе и высокую – в 1-й контрольной. Ключевые слова: мочекаменная болезнь, рецидивный уролитиаз, почечные камни, остеопороз, физико-химические и биохимические показатели мочи и крови, трансуретральная и перкутанная нефролитотрипсия, рентгеновская дифрактометрия, инфракрасная спектроскопия, поляризационная и электронная микроскопия, минеральный состав мочевых камней, андрогензаместительная терапия. The main and the first control group consisted of 40 patients with recurrent urolithiasis without urinary tract obstruction after endoscopic stone removal and partial androgen deficiency. The results of therapy and follow-up care for 6 years showed a low recurrence of stone formation in patients of the main group and highest in the control.
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