Abstract
Iron metabolism disorders are frequent in chronic diffuse liver diseases (CLD). Aims - to determine the peculiarities iron metabolism in patients with CLD and to develop diagnostic algorithm. Methods - complex clinical and morphologic investigation the iron metabolism in 167 clinical and 142 sectional cases of different CLD. Results - Laboratory signs of iron deficiency was disclosed in 26 (15,5%) and signs iron overload (IO) was determined in 35 (20,9%) CLD patients (n = 167). A liver hemosiderosis was discovered in 66 (46,5%) sectional cases CLD (n = 142). A HFE gene mutations was revealed in 11 (36,7%) of 30 CLD patients with IO. Conclusions - To order all CLD patients the iron metabolism disorders screening. Diagnostic algorithm was developed due to investigation results and modern requirements. Our algorithm provides the differentiated approach to diagnostic iron metabolism disorders in CLD patients.
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