Diagnostic yield of combined magnetic resonance spectroscopy and diffusion weighted imaging in intracranial neoplasms

Abstract

PurposeOur intention was to evaluate the role of combined diffusion magnetic resonance imaging and spectroscopy in diagnosis and grading of brain tumors. Materials and methodsNinety-three included cases underwent magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of the brain lesion, stereotactic or open biopsies and histopathological examination. MRI protocol included DWI and calculated ADC values. Multivoxel MRS spectroscopic technique (MVS) was used and all MRS metabolic parameters were obtained. ResultsHigh grade tumors had significantly lower ADC values than low grade tumors (P<0.001). ADC values were the lowest in lymphoma (0.54×10−3mm2/s) and the highest in craniopharyngioma (1.9×10−3mm2/s). MRS revealed a statistically significant difference in CHO/NAA and CHO/Cr ratios between low and high grade tumors with P<0.01 and P<0.001, respectively. The mI/Cr ratio and presence of lactate, lipid and taurine also aided in differentiation and grading of brain tumors. The overall MRI/MRS sensitivity and specificity were 91%, 90.5%, respectively. ConclusionMRS has a robust diagnostic accuracy in cases of well defined high or low grade brain neoplasms. ADC value had the ability to confirm and differentiate low from high grade tumors in many situations where there were diagnostic confusions with MRS due to borderline values.