Abstract
Abstract Abstract Iron deficiency (ID) is defined as a diminished total body iron content. Three degrees of severity have been defined: storage iron depletion (stage I), iron-deficient erythropoiesis (stage II), and iron deficiency anemia (stage III). When assessing the patient’s iron status, it is important to bear in mind that each of the various iron tests indicate something different in terms of ID. As they detect different stages of ID, the parameters efficiently complement each other to characterize the iron status in the individual patient. Of particular clinical interest are newer iron tests of the iron-deficient erythropoiesis: zinc protoporphyrin (ZPP), soluble transferrin receptor (sTfR), hypochrome erythrocytes (Hypo) and reticulocyte hemoglobin (CHr). Supervising the final step of the heme production, ZPP can be used as a reliable and inexpensive screening test of the whole iron metabolism. sTfR measurement is a useful tool to distinguish between real iron deficiency and functional iron deficiency in anemia of chronic disorders. Hypo and CHr seem to be the best parameters to diagnose ID in hemodialysis patients treated with recombinant human erythropoietin.
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