Abstract
An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth. At the same time, neonatal sepsis in the early period still predetermine sickness and mortality of newborns. Material and methods. Clinical-paraclinical indices with detection of diagnostic value of C-reactive protein and interleukins-6 and 8 were evaluated in 100 neonates with available susceptibility factors to early neonatal infection from mother’s side and clinical signs of organ dysfunction in neonates with precautions of generalized infectious-inflammatory process at the end of their first day of life. Results. The data obtained substantiate that low concentrations of IL-6 and IL-8 prevail, and therefore the mentioned mediators hardly can be used to verify early neonatal infection. In the majority of children C-reactive protein elevated the concentration of 10.0 mg/L which is traditionally considered to be a discriminant as to the verification of an infectious process in newborns. Conclusions. None of the clinical signs associated with infectious-inflammatory process in newborns in the first two days of their life enabled to verify reliably availability of systemic bacterial infection.
Highlights
An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth [1]
C-reactive protein is synthesized by the liver under the effect of interleukin-6 and interleukin-1β
Respiratory changes presented a larger spectrum of clinical signs
Summary
An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth [1]. It is explained by the fact that clinical signs of infectious pathology both in term and preterm infants are minimal, obliterated and nonspecific They can be provoked by non-infectious causes promoting the development of tachypnea of newborns, thermal imbalance under the influence of environmental factors, apnea of preterm neonates and other numerous clinical syndromes [6]. In recent times neonatologists have set their great hopes on detection of proteins of acute inflammatory phase and anti-inflammatory cytokines in the blood of neonates as reliable markers of neonatal infection [7, 8]. The diagnostic value of C-reactive protein in detection of neonatal infection is found to increase considerably in case serial examinations are performed [10]
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