Abstract

Objective To investigate the value of virtual bronchoscopic navigation guided transbronchial lung biopsy for peripheral pulmonary solitary nodules. Methods 96 patients with peripheral pulmonary lesions who experienced different manners of transbronchial lung biopsy in the First Affiliated Hospital of Chengdu Medical College between January and December 2016 were analyzed retrospectively. The patients were divided into a conventional forceps biopsy group, a virtual bronchoscopic navigation guided forceps biopsy group, a virtual bronchoscopic navigation guided cryorecanalization group. We compared the diagnostic yield and operation time among former three groups. Results The lesion size of the conventional forceps biopsy group, the virtual bronchoscopic navigation guided forceps biopsy group, the virtual bronchoscopic navigation guided cryorecanalization group were (21±7)mm, (22±8)mm, (19±8)mm. Furthermore, no significant difference was found in diagnostic yields by lesion size (F=0.48, P=0.54). The conventional forceps biopsy group had the lowest diagnostic yield(43.3%, 13/30) among the three groups(χ2=7.801, P=0.020). And there was no significant difference in the diagnostic yield between the virtual bronchoscopic navigation guided forceps biopsy group and the virtual bronchoscopic navigation guided cryorecanalization group(χ2=1.099, P=0.295). The virtual bronchoscopic navigation guided forceps biopsy group and the virtual bronchoscopic navigation guided cryorecanalization group did not have any variety in lesion location by pulmonary segment and histological findings. The procedure time remained significantly longer in the virtual bronchoscopic navigation guided forceps biopsy group(436±201)s than the virtual bronchoscopic navigation guided cryorecanalization group(363±185)s(t=1.56, P=0.038). Conclusions The virtual bronchoscopic navigation guided transbronchial lung biopsy might enhance the diagnostic yield in peripheral pulmonary lesions, and virtual bronchoscopic navigation cryorecanalization could decrease the procedure time. Key words: Biopsy; Transbronchial lung biopsy; Virtual bronchoscopic navigation; Pulmonary

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