Abstract
In this study, we evaluated the clinical diagnostic value of vestibular evoked myogenic potentials (VEMPs) for endolymphatic hydrops (EH) by systematic review and Meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under summary receiver operating characteristic curves (AUC) were calculated. Subgroup analysis and publication bias assessment were also conducted. The pooled sensitivity and the specificity were 49% (95% CI: 46% to 51%) and 95% (95% CI: 94% to 96%), respectively. The pooled positive likelihood ratio was 18.01 (95% CI: 9.45 to 34.29) and the pooled negative likelihood ratio was 0.54 (95% CI: 0.47 to 0.61). AUC was 0.78 and the pooled diagnostic odds ratio of VEMPs was 39.89 (95% CI: 20.13 to 79.03). In conclusion, our present meta-analysis has demonstrated that VEMPs test alone is not sufficient for Meniere’s disease or delayed endolymphatic hydrops diagnosis, but that it might be an important component of a test battery for diagnosing Meniere’s disease or delayed endolymphatic hydrops. Moreover, VEMPs, due to its high specificity and non-invasive nature, might be used as a screening tool for EH.
Highlights
In this study, we evaluated the clinical diagnostic value of vestibular evoked myogenic potentials (VEMPs) for endolymphatic hydrops (EH) by systematic review and Meta-analysis
We focused on EH, a histopathological hallmark of both Meniere’s disease (MD) and Delayed endolymphatic hydrops (DEH), to explore the diagnostic value of VEMPs
Previous studies have intensively explored the diagnostic value of VEMPs for MD or DEH, and the findings varied substantially with different researches. In this meta-analysis, we comprehensively summarized the results of prior results with an attempt to precisely evaluate the usefulness of VEMPS in the diagnosis of EH due to MD or DEH
Summary
We evaluated the clinical diagnostic value of vestibular evoked myogenic potentials (VEMPs) for endolymphatic hydrops (EH) by systematic review and Meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under summary receiver operating characteristic curves (AUC) were calculated. AUC was 0.78 and the pooled diagnostic odds ratio of VEMPs was. Its symptoms include recurrent episodes of self-limiting vertigo, fluctuating or progressive sensorineural hearing loss, fullness and tinnitus of the affected ear. Over the past two decades, mounting evidence has demonstrated that MD may present a variety of clinical symptoms and respond differently to treatment and possesses a wide array of phenotypical and endophenotypical features of inner ear disorders[1,2,3]. Delayed endolymphatic hydrops (DEH) is defined as delayed development of episodic vertigo following either ipsilateral or contralateral ear with profound sensorineural hearing loss[4]. Underlying pathological state of MD is idiopathic EH, while, DEH is one form of secondary EH
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
