Abstract
Diagnostic value of urinary retinol binding protein (RBP), albumin (ALB) and aquaporin-2 (AQP2) in neonatal hydronephrosis and their relationship with the expression of monocyte chemoattractant protein 1 (MCP-1) in the prenatal maternal peripheral blood was investigated. Forty-six child patients with hydronephrosis admitted to Hongqi Hospital Affiliated to Mudanjiang Medical College from December 2016 to November 2017 were selected as the observation group and the control included 46 normal newborn infants. The urinary RBP, ALB, AQP2 and the expression of MCP-1 in the prenatal maternal peripheral blood in the two groups were compared. The diagnostic value of the combination of urinary RBP, ALB and AQP2 for the neonatal hydronephrosis was accessed through the area under curve (AUC). The changes of urinary RBP, ALB and AQP2 of child patients were observed and the correlations between RBP, ALB, AQP2 and MCP-1 were analyzed. The concentrations of RBP and ALB in the observation group were obviously increased compared to those in the control group. The AQP2 concentration in the observation group was lower than that in the control group. In the observation group, the MCP-1 level in the prenatal maternal blood was significantly higher than that in the control group (P<0.05). After treatment, the concentration of RBP and ALB in the child patients were significantly decreased and AQP2 concentration was increased compared with that before treatment (P<0.05). The AUC of the diagnosis combining with RBP, ALB and AQP2 was 0.913. RBP and ALB were positively correlated to MCP-1 in the prenatal maternal peripheral blood and there was a negative correlation between AQP2 and MCP-1 (P<0.05). In conclusion, urinary RBP, ALB and AQP2 can be regarded as markers for the diagnosis of the neonatal hydronephrosis and they are also closely related to the MCP-1 level in the prenatal maternal peripheral blood.
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