Abstract
Objective To explore the value of T-SPOT.TB test in the diagnosis of tuberculous pleurisy. Methods The positive rate, sensitivity, specificity, positive predictive value, and negative predictive value of T-SPOT.TB and ADA were calculated and compared. Among these patients, 40 were retested by T-SPOT.TB after anti-tuberculosis treatment; and spot forming cells (SFCs) were compared before and after the treatment. Results The sensitivity, specificity, positive predictive value, and negative predictive value of T-SPOT.TB were 89.66%, 86.54%, 88.14%, 88.24%, and 0.76. And those of ADA were 74.14%, 75.00%, 76.79%, 72.22%, and 0.49. The sensitivity and specificity of T-SPOT.TB were significantly higher than those of ADA, with statistical differences (P<0.05). 40 patients were retested by the T-SPOT.TB after anti-TB treatment, and the results showed that ESAT-6 and CFP-10 specific SFCs decreased significantly compared with those before anti-TB treatment (P<0.05). Conclusion T-SPOT.TB assay has an important clinical value in the diagnosis of tuberculous pleurisy and help us monitor treatment response. Key words: T-SPOT.TB; ADA; Tuberculouspleurisy; Diagnostic value
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