Abstract
Objective To explore the diagnostic value of serum heparin binding protein (HBP), blood lactic acid (Lac) combined with high-sensitivity C- reactive protein (hs-CRP) in sepsis and its relationship with prognosis. Methods The clinical data of 127 patients with sepsis from March 2019 to March 2021 in our hospital were retrospectively analyzed. 120 outpatients undergoing physical examination in the same period in our hospital were selected as the control group. According to the severity of the disease, 127 sepsis patients were divided into the mild sepsis group (n = 45), severe sepsis group (n = 53), and septic shock group (n = 29). According to the clinical prognosis, the patients were divided into the survival group (n = 96) and death group (n = 31). Serum HBP, Lac, and hs-CRP levels were measured in all subjects. The ROC curves of the subjects were drawn to analyze the predictive value of serum HBP, Lac, and hs-CRP for the prognosis of sepsis patients. Results The levels of serum HBP, Lac, and hs-CRP in the sepsis group were higher than those in the control group (P < 0.05). With the increase of the severity of sepsis, serum HBP, Lac, and hs-CRP levels of patients gradually increased (P < 0.05). The levels of serum HBP, Lac, and hs-CRP in the death group were higher than those in the survival group (P < 0.05). The AUC of serum HBP, Lac, and hs-CRP for predicting the prognosis of sepsis patients was 0.858 (95% CI: 0.763–0.953), 0.694 (95% CI: 0.589–0.799), and 0.843 (95% CI: 0.759–0.927). The AUC of serum HBP, Lac combined with hs-CRP for predicting the prognosis of sepsis patients was 0.961 (95% CI: 0.000–1.000). Conclusion The levels of serum HBP, Lac, and hs-CRP in patients with sepsis were significantly increased and increased with the severity of sepsis. Serum HBP, Lac, and hs-CRP have a good value in predicting the prognosis of patients with sepsis and worthy of clinical application.
Highlights
Sepsis is a systemic inflammatory response syndrome that causes pathophysiological changes of the immune system due to pathogen infection and has become a common critical illness in the clinic [1]. e condition of sepsis is dangerous and progresses rapidly
Serum heparin binding protein (HBP), lactic acid (Lac), and highsensitivity C- reactive protein (hs-C-reactive protein (CRP)) levels were measured in all subjects after passing the indoor quality control. e HBP level was determined with the enzymelinked immunosorbent assay (ELISA), Lac level was determined with the enzyme electrode method, and hs-CRP level was determined with immunoturbidimetry
3.4. e Predictive Value of Serum HBP, Lac, and hs-CRP on the Prognosis of Patients with Sepsis. e AUC of serum HBP, Lac, and hs-CRP for predicting the prognosis of sepsis patients were 0.858, 0.694, and 0.843. e AUC of serum HBP, Lac combined with hs-CRP for predicting the prognosis of sepsis patients was 0.961, as given in Table 5 and Figure 1
Summary
Sepsis is a systemic inflammatory response syndrome that causes pathophysiological changes of the immune system due to pathogen infection and has become a common critical illness in the clinic [1]. e condition of sepsis is dangerous and progresses rapidly. E condition of sepsis is dangerous and progresses rapidly. Sepsis is a systemic inflammatory response syndrome that causes pathophysiological changes of the immune system due to pathogen infection and has become a common critical illness in the clinic [1]. If it is not treated with timely and appropriate intervention, the condition will further deteriorate, and even there will be a life-threatening multiorgan dysfunction syndrome, which has posed a serious threat to the life safety of patients [2]. Bacteriology is an important reference for the diagnosis of sepsis, and the most common pathogenic factors are Gram-positive and Gram-negative
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