Abstract
Objective To investigate the clinical value of combined detection of serum serum carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), integrin metal protease 8 (ADAM8) and cytokeratin (CYFRA21) in the diagnosis of non-small cell lung cancer. Methods A total of 120 patients with non-small cell lung cancer were selected as this study. All the patients were randomly divided into two groups, 60 cases in each group. Two groups of patients were selected by mod-el550 and electrochemiluminescence assay to carry out enzyme-linked immunosorbent assay. In the control group, serum CEA, SCC, ADAM8 and CYFRA21 were measured and calculated at the wavelength of 450 nm, 410 nm and 600 nm. The accuracy and sensitivity of non-small cell lung cancer (NSCLC) were determined by the study group on the control group, and calculated it. Results The levels of CEA, SCC, ADAM8 and CYFRA21 in the serum of the study group were significantly higher than that in the control group (P<0.05). The accuracy and sensitivity of CEA, SCC, ADAM8 and CYFRA21 in the serum of the study group were significantly higher than those in the control group (P<0.05). Conclusions The combination of CEA, SCC, ADAM8 and CYFRA21 in the serum joint detection of the non-small cell lung cancer, which can greatly improve the accuracy and sensitivity of the detection, and the effect is good. It is worthy of clinical application. Key words: Serum carcinoembryonic antigen; Squamous cell carcinoma antigen; Integrin metalloproteinase 8; Cytokeratin; Non-small cell lung cancer
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