Abstract
Diagnostic Value of Serum Adenosine Deaminase in Type II Saudi Diabetic Patients
Highlights
Diabetes mellitus (DM) is one of the most causative important factors of mortality in the developing countries where it affects more than 170 million persons all over the world [1]
Non-significant differences were observed between the two groups in cystolic or diastolic blood pressure, while slightly significant decrease was observed in body mass index (BMI) in type 2 DM group compared to the control group
Highly significant decreases (P < 0.001) are found in the mean erythrocytes glutathione peroxidase (GPX) and erythrocytes Superoxide dismutase (SOD) activities of the patients of the four diabetic groups compared to the controls
Summary
Diabetes mellitus (DM) is one of the most causative important factors of mortality in the developing countries where it affects more than 170 million persons all over the world [1]. It is characterized by insulin deficiency either in secretion or action or both which leads to hyperglycemia and the disturbances of carbohydrate, lipid, and protein metabolism [2]. Several studies have demonstrated the increase in adenosine deaminase in patients with type 2 diabetes mellitus. Adenosine deaminase (ADA) is a purine metabolizing enzyme that catalyzes the deamination of adenosine to inosine. Serum levels of ADA, total cholesterol (TC), triglycerides (TG), glycosylated hemoglobin (HbA1c), alanine amino transferase (ALT), aspartate amino transferase (AST), urea, creatinine, uric acid, Malondialdhyde (MDA), Glutathione Peroxidase (GPx) and Superoxide dismutase (SOD) were measured
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