Abstract
BackgroundNeedle core biopsy (NCB) is one of the most widely used and accepted methods for the diagnosis of focal hepatic lesions. Although many studies have assessed the diagnostic accuracy of NCB in predicting the tumor grade, it is still under debate.ObjectiveTo identify the influence of number of biopsies on NCB diagnostic accuracy.Methods153 patients with HCC were selected from patients who received preoperative NCB under the guidance of ultrasonography in our hospital. The diagnostic reference standard was the surgical pathologic diagnosis.ResultsUsing a 3-tier grading scheme (well, moderate and poor), the accuracy of NCB has no significant differences among different number of passes in HCC ≤5cm. For HCC >5≤8cm, the increasing number of passes could increase the diagnostic accuracy (63.3%, 81.8%, and 84.8% for passes one, two, and three, respectively). While in HCC>8cm, the diagnostic accuracy of passes one, two, and three were 62.1%, 69%, and 75.8%, respectively.ConclusionsThe accuracy of NCB in assessing tumor grading associated with tumor size and number of passes. Meanwhile, a minimum of two passes should be performed to get better accuracy in patients with HCC >5cm.
Highlights
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated mortality globally [1, 2]
Using a 3-tier grading scheme, the accuracy of Needle core biopsy (NCB) has no significant differences among different number of passes in HCC 5cm
The accuracy of NCB in assessing tumor grading associated with tumor size and number of passes
Summary
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated mortality globally [1, 2]. The screening of HCC in at-risk patients relies on measuring the serum level of alpha-fetoprotein (AFP) and ultrasound examination [3]. These screening methodologies are unable to identify the molecular typing of HCC and preoperative tumor grade; AFP’s sensitivity in screening of HCC is very limited as increased level of AFP has been reported in many other liver diseases as well [4, 5]. Needle core biopsy (NCB) is a widely used and accepted methods for obtaining tumor tissue samples. Needle core biopsy (NCB) is one of the most widely used and accepted methods for the diagnosis of focal hepatic lesions. Many studies have assessed the diagnostic accuracy of NCB in predicting the tumor grade, it is still under debate
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