Abstract
Introduction. Ischemic maculopathy is the main cause of irreversible vision loss due to retinal vein occlusion (RVO). Fluorescein angiography (FA), which is the gold standard for evaluating retinal capillary plexuses, does not allow for the visualization of separate intraretinal capillary networks. Optical coherence tomography angiography (OCT-angiography) enables the possible visualization of four capillary plexi and allows for the quantitative analysis of microcirculation to quantitatively estimate capillary network density and non-perfusion areas.
 Aim. To investigate microcirculation changes using OCT-angiography data and to compare the changes with opthalmoplethysmography indices in patients with RVO.
 Material and methods. The study included 12 patients with RVO. In all patients, a routine ophthalmic examination was performed, and ocular blood flow was estimated using FA, OCT-angiography, and ophthalmoplethysmography.
 Results. Ischemia in the macular area was detected in four patients (25%) according to FA results, and in eight (67%) accor ding to OCT-angiography data. Compared with the unaffected eye, significant decrease in the density of both superficial and deep capillary plexuses as well as a decrease in flow area and enlargement of foveal avascular zone were observed. A significant close direct correlation was established between capillary density in the superficial capillary plexus (r 0.8) and the deep capillary plexus (r 0.7), choroidal thickness, and opthalmoplethysmography indices (r 0.6).
 Conclusion. Compared with FA, OCT-angiography is a more sensitive method to detect macular capillary perfusion. In cases with RVO, the combination of the above mentioned methods with ophthalmoplethysmography allows for the comprehensive evaluation of regional hemodynamics.
Highlights
Ischemic maculopathy is the main cause of irreversible vision loss due to retinal vein occlusion (RVO)
Ischemia in the macular area was detected in 4 patients (25%) according to Fluorescent angiography (FA) results, and in 8 (67%) according to OCT-angiography data
Significant close direct correlation was established between capillary density in the superficial capillary plexus (r > 0.8) and the deep one (r > 0.7), choroidal thickness, and opthalmoplethysmography indices (r > 0.6)
Summary
Ишемическая макулопатия — основная причина необратимого снижения зрения при окклюзии вен сетчатки (ОВС). Оптическая когерентная томография-ангиография (ОКТангиография) даёт возможность визуализировать четыре капиллярных сплетения и позволяет проводить количественный анализ микроциркуляции с расчётом плотности капиллярной сети и зон отсутствия капиллярной перфузии. Цель: изучить у больных с ОВС особенности изменения микроциркуляции по данным ОКТ-ангиографии и сопоставить их с показателями офтальмоплетизмографии. Всем пациентам проводилось стандартное офтальмологическое обследование с дополнительной оценкой регионарной гемодинамики с помощью ФАГ, ОКТ-ангиографии и офтальмоплетизмографии. У больных с ОВС по данным ФАГ ишемия в центральной зоне выявлена у 4 пациентов (25 %), а по данным ангиографии ОКТ — у 8 (67 %). Сочетание обсуждаемых методов с выполнением офтальмоплетизмографии позволяет провести комплексную оценку регионарной гемодинамики при окклюзии вен сетчатки. Ключевые слова: окклюзии вен сетчатки; глазной кровоток; ишемия сетчатки; капиллярная перфузия; ОКТ-ангиография; офтальмоплетизмография. Titarenko First Pavlov State Medical University of St Petersburg, Saint Petersburg
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