Diagnostic value of neutrophil CD64 combined with CRP for neonatal sepsis: A meta-analysis

Abstract

BackgroundSepsis is the leading cause of morbidity and mortality in newborns. CD64 combined with c-reactive protein (CRP) could improve the sensitivity and specificity of neonatal sepsis diagnosis, but the results were still controversial. Therefore, this meta-analysis was conducted to clarify the importance of CD64 combined with CRP in the diagnosis of neonatal sepsis. MethodsThe researches published as of December 24, 2018 were comprehensively searched in PubMed, Embase (included Embase and Medline), the Cochrane Library and Web of Science. Totally, 8 articles were included, involving 1114 objects. Statistical calculations were performed using Stata14.0 and Review Manager 5.3. ResultsThe diagnostic accuracy of all included studies was pooled as follows: sensitivity, 0.95 (95% CI: 0.86–0.98); specificity, 0.86 (95% CI: 0.74–0.93); positive likelihood ratio (PLR), 6.8 (95% CI: 3.50–13.20); negative likelihood ratio (NLR), 0.06 (95% CI: 0.02–0.18); diagnostic odds ratio (DOR), 118.0 (95% CI: 25.00–549.00), and the area under the curve (AUC) was 0.96 (95% CI: 0.94–0.97). It was found that heterogeneity was not caused by threshold effect (P = 0.16), but the results of sensitivity (I2 = 87.57%) and specificity (I2 = 89.07%) analyses indicated significant heterogeneity between studies. ConclusionsThe combined application of CD64 and CRP improved the accuracy of neonatal sepsis diagnosis.