Abstract
Background: Chronic liver disorders in children constitute an increasing concern with major public health impacts, the MMP is degrading diverse extracellular matrix macromolecules and involves tissue reshaping and repair in physiological processes. The purpose of this research was to assess the diagnostic usefulness of MMP-1 in children with chronic liver disorders. Methods: 60 children undertook this research; Group I (hepatic group): 60 children with chronic liver disease, Group II (control group): 20 seemingly healthy youngsters, The entire history of taking, comprehensive clinical examination, abdominal US and laboratory testing like a complete blood count and liver function tests have been performed for all children (Alt, AST, Albumin, PT, PTT, INR, Total and direct bilirubin), Liver biopsy was conducted in all patients, with human enzyme-connected immunosorbent testing measuring Serum MMP-1 levels (ELISA). Results: the mean MMP-1 in hepatic group was 11.2±2.1 ng/ml and in control group 32.7±17.4 ng/ml. In the hepatic group controlled, p F1), AUC was 0.872 (95 percent confidence interval: 0.709-0.487), p F3); AUC p < 0.001. The sensitivity was 90% at cutoff point < 4.5 ng/ml and the specificity was 80%. Conclusion: Fibrosis identification in children with chronic liver disorders might benefit from MMP-1.
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