Diagnostic value of heparin-binding protein in the cerebrospinal fluid for purulent meningitis in children.

Dan Ren,Di Wu,Fu Liu,Yi Wu,Shuli Jiao

doi:10.1590/1414-431x2021e11295

Dan Ren, Di Wu + Show 3 more

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https://doi.org/10.1590/1414-431x2021e11295

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Abstract

This study aimed to investigate the diagnostic value of heparin-binding protein (HBP) in the cerebrospinal fluid of children with purulent meningitis (PM). This study included 118 children with PM diagnosed at our hospital from January 2018 to January 2020, 110 children with viral meningitis (VM) and 80 children with suspected meningitis who were ruled out by cerebrospinal fluid (CSF) analysis during the same period. HBP and white blood cell (WBC) count in the CSF, and inflammatory factors, including C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and procalcitonin (PCT), were measured. Receiver-operator characteristic curves were used to analyze the predictive value of HBP, CRP, PCT, and TNF-α levels in the diagnosis of PM by CSF analysis. HBP levels in the CSF of children with PM were higher, while the CRP and serum PCT and TNF-α levels were elevated in all groups (P<0.05). In addition, HBP levels in the CSF were more accurate for the diagnosis of PM than traditional diagnostic indexes. HBP levels in the CSF can be used as an important reference for early diagnosis of PM.

Highlights

Purulent meningitis (PM) is an infection of the meninges caused by a purulent bacterial infection and a common purulent infection of the central nervous system
heparin-binding protein (HBP) levels were higher in the cerebrospinal fluid (CSF) of the PM group than in that of the CON and viral meningitis (VM) groups (Po0.05, Figure 1), indicating that HBP levels in the CSF could be used as a potential indicator for the diagnosis of PM
CSFWBC levels were higher in the PM group than in the CON and VM groups (Po0.05, Figure 2), indicating that CSF-white blood cell (WBC) levels could be used as an indicator for the diagnosis of PM

Summary

Introduction

Purulent meningitis (PM) is an infection of the meninges caused by a purulent bacterial infection and a common purulent infection of the central nervous system. It is more common in children, and some children can show a severe condition and die within 24 h if they are not treated in time. Diagnosis of the disease is difficult to confirm due to the lack of apparent specific early clinical manifestations, which contributes to a higher rate of disability [3] and seriously affects the daily life of patients and their families.

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