Abstract

Objective To evaluate the diagnostic value of dynamic contrast enhanced MRI(DCE-MRI)in angiogenesis and invasion of ovarian tumors. Methods 98 patients with pathological-confirmed ovarian tumors without any treatment underwent plain MRI and DCE-MRI before operation. The plain MR images and DCE-MRI data were retrospectively analyzed. Value of Ktrans and Ve was detected by pharmacokinetic model. The expression of VEGF and MMP-2 in ovarian tumors was examined by immunohistochemistry. The correlation between DCE-MRI parameters and immunohistochemical results was analyzed. Results The expression of VEGF and MMP-2 was significantly higher in the malignant group compared with that in the benign group(both P<0.05). The value of Ktrans and Ve was significantly lower in the benign group compared with that in the malignant group(both P<0.05). The value of Ktrans and Ve was positively correlated with the expression of VEGF and MMP-2. Conclusion DCE-MRI can noninvasively evaluate the angiogenesis and invasion of ovarian tumors in vivo, which has important significance for clinical treatment and prognostic assessment. Key words: Dynamic contrast enhanced magnetic resonance imaging; Ovarian tumors; Angiogenesis; Invasion; VEGF; MMP-2

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