Diagnostic value of brain MR imaging and its correlation with clinical presentation and cognitive functions in idiopathic intracranial hypertension patients

Ali Ahmed Abou Elmaaty,Tamer Sabry Elserafy,Carmen Ali Zarad,Tamer Ibrahim Belal

doi:10.1186/s41983-021-00338-9

Abstract

BackgroundIdiopathic intracranial hypertension (IIH) is a neurological disorder of unknown etiology and ambiguous pathophysiology due to cerebrospinal fluid dysregulation. This study is designed to evaluate the role of brain magnetic resonance imaging (MRI) and magnetic resonance venography (MRV) in diagnosis of IIH, to clarify the nature and extent of cognitive deficits, and to detect if there is a correlation between radiology, clinical findings, and cognitive dysfunctions in those patients.ResultsThe study included 34 patients and 34 age-, sex-, body mass index (BMI)-, and education-matched healthy control subjects. MR brain imaging and Montreal cognitive assessment (MoCA) test were used for both groups. MRI and MRV sensitivity for IIH diagnosis were 85.2% and 85.3% with 100% and 94.1% specificity respectively. 44.1% had cognitive impairment, memory was the most affected domain, followed by attention, abstraction, and orientation with statistically significantly lower total MoCA score (p < 0.005). Domain comparisons reveal a statistically significantly lower memory/delayed recall (p < 0.001) and abstract scores (p < 0.007) in IIH cases versus control subjects. In comparing patients with cognitive impairment (CI) versus those without CI, there were statistically significantly higher CI in low education level, presence of diplopia, hormonal contraceptive use, abnormal MRI brain, papilledema grades, BMI, and opening pressure.ConclusionsPresence of more than or equal 3 MR imaging findings, bilateral transverse sinus stenosis, and less than or equal 4 combined conduit score increase the specificity and sensitivity of MRI and MRV for IIH diagnosis. IIH had detrimental effect on different cognitive domains especially when patient have low education level, diplopia, papilledema ≥ grade III, high OP ≥ 61.5 cm H2O, and BMI ≥ 34 Kg/m2 with abnormal MRI and MRV findings.

Highlights

Idiopathic intracranial hypertension (IIH) is a neurological disorder of unknown etiology and ambiguous pathophysiology due to cerebrospinal fluid dysregulation
Idiopathic intracranial hypertension (IIH) is a neurological disorder of unknown etiology characterized by increased intracranial pressure (ICP) and normal composition of cerebrospinal fluid (CSF) with elevated opening pressure (OP) [1]
In this study, comparing patients with cognitive impairment with patients with normal cognitive function, we found that low education level showed statistically significant lower cognitive function when compared with high education level (P = 0.042) which may be attributed to social state; this is consistent with Yri and his colleagues; they found that IIH is a state of socioeconomic consequences especially for young patients of working age [25]

Summary

Introduction

Idiopathic intracranial hypertension (IIH) is a neurological disorder of unknown etiology and ambiguous pathophysiology due to cerebrospinal fluid dysregulation. Idiopathic intracranial hypertension (IIH) is a neurological disorder of unknown etiology characterized by increased intracranial pressure (ICP) and normal composition of cerebrospinal fluid (CSF) with elevated opening pressure (OP) [1]. IIH commonly affects obese women in childbearing age; it can affect men, children, and non- obese individuals [3]. It has insidious onset with subsequent delayed diagnosis [4]. Cognition is not screened routinely during clinical evaluation of IIH, many recent researches were done for assessment of cognitive function and reported cognitive impairment (CI) in these patients [9]

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