Abstract
Summary 1.Clinical experience with a new method of serum lipase determination is presented. The normal mean for serum lipase concentration is 4.5 units/ml. with a 95% confidence range of 1 to 10 units. 2.Significant elevations of serum lipase were found in the 20 cases of acute pancreatitis studied. These elevations occurred early in the course of illness (within 24 hr) and were found to parallel those of serum amylase. 3.Elevation of serum lipase was not observed in 2 cases of inflammatory disease of the salivary gland. 4.No consistent elevations of serum amylase or lipase concentration were noted in 16 patients with liver disease or in 10 patients with carcinomatous involvement of the pancreas and liver. 5.Elevations of serum amylase concentrations were noted at relatively low levels of blood urea nitrogen (50 mg/100 ml) and elevation of both serum amylase and lipase concentration were noted with blood urea nitrogen of 77 mg/100 ml. However, some patients with elevated BUN did not have elevated enzyme levels. 6.The short hydrolysis period (1 hr) and the sensitivity for detection of acute pancreatic injury of this new lipase method make it a rapid, practical, and reliable test in the diagnosis of acute pancreatitis.
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