Diagnostic Validation Study. Relationship Between Optical Spectroscopy and Ankle Brachial Index Tests for Peripheral Artery Disease.

Abstract

Ankle brachial index (ABI)is an essentialdiagnostic test for peripheral artery disease. It has some important limitationsso it can´t always be performed.In those cases, tissue oximetry based on near-infrared spectrum could overcome these limitations. Assessment ofthe relationship between ABI and tissue oximetry tests and the ability of the oximetry to detect postoperative improvement. Prospective observational study. Several measures were made by both, ankle pressure and tissue oximetry tests, in lower limbs. Absolute values were collected at foot level (anterior and posterior tibial arteries) and the indexes were calculated in relation to a control (upper limbs for ABI and left infraclavicular region for tissue oximetry). In order to evaluate the correlation between ankle pressure and tissue oximetry values, Pearson correlation coefficient and linear regression analyses were applied. T-Student and ROC curve analysis were made to evaluate thepostoperative improvement detected by bothankle pressureandtissue oximetry tests. 60 patients with peripheral artery disease were included. Ankle pressure and tissue oximetry were measured in 70 lower limbs, in 45 of them before and after revascularization. Compared to ankle pressure, tissue oximetry was able to detect improvement in absolute values and indexes after revascularization. This indexes improvement was parallel (P=0.234 for anterior tibial artery and P=0.356 for posterior tibial artery). We weren´t able to determine a cutoff point between both tests (ROC curve analysis).We observed a significative positive correlation in absolute values of both tests (Pearson correlation coefficient, r=0,281; P < 0.001). Tissue oximetry is able to detect improvement after revascularization of lower limbs.