Abstract
Background: Vascular Thromboembolism (VTE)- blockage of a blood vessel by the broken components of a blood clot, is commonly caused by Thromboembolism Deep venous thrombosis (DVT) and Pulmonary embolism (PE). It can also be caused by various other conditions, and have overlapping features. VTE's have signicant morbidity and mortality, treatment carries signicant side effects, hence, objective testing becomes must to establish or exclude the presence of thromboembolism. D-Dimer, a brin degradation product (FDP), appears in blood after degradation of blood clot by brinolysis. It is normally undetectable or detectable at a very low level, unless the body is forming and breaking down blood clots as in VTE. Materials and Methods: Quantitative D-Dimer test was performed using fully automated technique, on patient's serum. Latex particles coated with anti D-dimer monoclonal antibodies were mixed with the test plasma. In the presence of D-dimer, the latex particles agglutinate, the suspension claries and translates in low turbidimetric readings. All results were further correlated with their CT Angiography ndings.Results: Most patients had D-Dimer value in range of 1.0 to 2.0 µg/ml. High (96.77%) Sensitivity shows that the test can be used safely to detect Thromboembolism even in early stages, whereas, High Negative Predictive value (93.54%), suggests safe exclusion in suspected cases. Conclusion: D-Dimer is highly sensitive, accurate and rapid test, but alone cannot conclude diagnosis. It is advisable to correlate with combination of Radiological investigations (CT Angiography) and clinical probability- Revised Geneva score and to establish a nal diagnosis and plan an appropriate treatment.
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