Abstract
This study was aimed to describe the endoscopic picture and laboratory findings in children with chronic abdominal pain and to determine the utility of nodular gastritis in diagnosing HPI in these patients. This prospective study was done between November, 2004 and May, 2007. A total of 70 patients (36 male and 34 female) aged 3-14 years, underwent upper endoscopy. H-pylori infection was diagnosed when both urease test and histology were positive for the infection. Seventy percent (n = 49) of them were diagnosed to have endoscopic nodular gastritis. HPI was confirmed in 33 (47.1%) of 70 patients. The endoscopic antral nodularity had a sensitivity of 100%, specificity of 56.8%, positive predictive value of 67.3%, negative predictive value of 100% and a positive LR of 2.32 for diagnosis of HPI. It may be recommended that if nodular gastritis observed in a pediatric patient with chronic abdominal pain he/she should be investigated to exclude HPI otherwise no further work up is necessary to confirm HPI.
Highlights
In children, Helicobacter pylori (HPI) is usually colonized before the age of 5 and if not cured it will lastLifelong
HPI is the most common cause of chronic gastritis, gastric ulcer (25%) and duodenal ulcer (90%)[2,3]. This micro-organism is observed in 30-100 percent of children with endoscopic nodular gastritis[2]
Between November, 2004 and May, 2007 this study was prospectively done on 70 children between 3 to 14 years old who had referred to a tertiary care outpatient center with chief complaint of chronic abdominal pain
Summary
This phenomenon is specially more common in developing countries and affects up to 80% of children under the age of 10[1]. HPI is the most common cause of chronic gastritis, gastric ulcer (25%) and duodenal ulcer (90%)[2,3]. This micro-organism is observed in 30-100 percent of children with endoscopic nodular gastritis[2]. It is found in the gastric mucosa or attached to the epithelial lining of only the human stomach[4]. The role of this pathogen in gastric cancer and maltoma is well known[2,5]
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