Abstract
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare genetic arrhythmia predisposing to a high risk of sudden death during periods of adrenergic stress. The diagnosis hinges on the exercise stress test, which induces progressive polymorphic and bidirectional ventricular arrhythmias in affected patients. Genetic testing usually identifies a missense variant in the cardiac ryanodine receptor (RyR2). When arrhythmia symptoms are reported by patients, it is also common to perform a Holter monitor, which may identify ventricular arrhythmias.
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