Abstract
Summary Background: This study aimed to determine adenosine deaminase (ADA) activity as a possible screening tool in lung cancer patients. Methods: Blood samples were collected from 30 subjects with positive pathological tests and 62 patients with negative pathological tests as a control group. The enzymatic activity of total ADA and its isoenzymes was determined. Results: tADA and ADA2 isoenzyme activity was significantly higher in cancerous patients compared to benign controls in serum and BAL fluid. Using a cut-off level of respectively 35.22 U/L and 31.80 U/L for BAL total ADA and ADA2, sensitivity and specificity were 100% and 81% for total ADA and 95% and 98% for ADA2. Conclusions: Adenosine deaminase may play important roles in the pathophysiology of lung cancer and because of its might be considered as a useful screening tool among the other markers in lung cancer diagnosis.
Highlights
Lung cancer is the most frequent cancer and the most important cause of cancer-related death in men
Regardless of histological type and staging, for the investigation of adenosine deaminase (ADA) utility in the screening of lung cancer, this study aimed to evaluate the alterations in serum total ADA levels as well as ADA1 and ADA2 isoenzyme activities and the correlation between ADA activity in serum and bronhoalveolarnom lavau (BAL) of lung cancer patients compared to control subjects
Our results showed higher ADA activity in patients with lung cancer compared to controls
Summary
Lung cancer is the most frequent cancer and the most important cause of cancer-related death in men. About one to two million people die from lung cancer every year worldwide. Lung cancer causes more deaths than the other three most common cancers combined, i.e., colon, breast and prostate [1, 2]. In an attempt to describe human lung cancer, many studies have concentrated on enzyme activities [3,4,5]. Some studies established alteration of enzyme activity in bronchoalveolar lavage [6, 7]. To better understand purine enzymology in lung cancer, more attention has been paid to the investigation of the interrelationship among the carcinogenic process and enzyme activity (de novo and salvage pathways) for purine biosynthesis [3, 4]
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