Diagnostic Tests Of Blood Glucose: A Systematic Review.

Abstract

To evaluate the accuracy of different blood glucose determination methods, and provide a theoretical basis for governments to determine the mainstream glucose detection methods. The MEDLINE, EMBASE, EBM REVIEWS, CBM, CNKI, Wanfang, Google academic search et al were were retrieved for literatures collection, literature quality evaluation was implemented by using QUADAS criteria, meta-analysis was carried out using Stata11.0 and heterogeneity test and sensitivity analysis was implemented. 20 studies were included, which contained a total of 2681 cases of patients. Meta analysis showed that values measured by the dry chemical method were significantly higher than glucose oxidase method, and no significant differences was found with the hexokinase method, no significant differences was yet found between the electrode method with enzyme method, the MD (95%CI) were 0.31 (0.09, 0.53), -0.51 (-0.14, 1.17) and -0.13, (-0.27, 0.02) respectively. Sensitivity analysis of the model, the sample source, research population, equipment and countries was carried out and conclusion was found no change between the methods. there was significant difference between different blood glucose detection methods; application of dry chemical measurement results should be cautious, we recommend using the glucose oxidase or diagnosis hexokinase method.