Abstract
To discuss the current strategies and impact of diagnostic stewardship for Clostridioides difficile infection. The diagnosis of C. difficile infection is challenging due to complex epidemiology and the limitations of a single assay that is adequate for diagnosis. Overdiagnosis with sensitive molecular assays is common due to the prevalence of colonization with C. difficile. To overcome these challenges, multiple diagnostic stewardship strategies have been successfully deployed to optimize C. difficile testing. Diagnostic stewardship strategies should be implemented at every stage of C. difficile testing in order to limit testing to patients with a high pre-test probability, minimize the limitations of stand-alone assays, and guide clinicians to appropriate management through clear result reporting and interpretation.
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