Abstract
BackgroundAs a result of the continuous rise in the incidence of type 2 diabetes mellitus (T2DM), related cardiovascular diseases (CVDs) have been a main healthy burden worldwide. This study aimed to investigate the potential role of FGD5-AS1 as a biomarker for the diagnosis of T2DM and predicting cardiovascular complications in T2DM.MethodsThree hundred subjects were recruited in this study, including 100 T2DM patients without CVDs, 100 T2DM patients with CVDs as well as 100 healthy subjects. Plasma FGD5-AS1 level was quantified using RT-qPCR assay. The correlation of FGD5-AS1 level with other key variables was assessed using Pearson correlation analysis. ROC curve analysis was performed to evaluate the diagnostic value of FGD5-AS1 for T2DM and related CVDs. The effect of FGD5-AS1 on AC16 and HA-VSMCs was determined.ResultsFGD5-AS1 level showed a stepwise decrease in individuals with T2DM and CVDs compared to healthy persons. FGD5-AS1 was associated with BMI, systolic blood pressure, diastolic blood pressure, fasting glucose, 2-h postprandial blood glucose, HbA1c, triglycerides, usCRP, and HDL-cholesterol. The ROC analysis indicated FGD5-AS1 had a significant overall predictive ability to diagnose T2DM, T2DM with CVDs, and the combination of both. FGD5-AS1 increases the growth but alleviates apoptosis and fibrosis of high glucose-induced AC16 cells. FGD5-AS1 attenuate the growth and calcification but induced apoptosis of high glucose-treated HA-VSMC cells.ConclusionsThese results suggest that FGD5-AS1 are associated with T2DM and measuring FGD5-AS1 could potentially contribute to T2DM screening and prediction for risk of cardiovascular complication.
Highlights
As a result of the continuous rise in the incidence of type 2 diabetes mellitus (T2DM), related cardiovascular diseases (CVDs) have been a main healthy burden worldwide
There is no difference in gender, age, and current smoking status among the three groups
Calcification assays HA-Vascular smooth muscle cells (VSMC) cells or transfected HA-VSMC cells were cultured with 30 mmol/L glucose for 14 days
Summary
As a result of the continuous rise in the incidence of type 2 diabetes mellitus (T2DM), related cardiovascular diseases (CVDs) have been a main healthy burden worldwide. Type 2 diabetes mellitus (T2DM) refers to a chronic health condition [1]. It has reached alarming rates, with an incidence of 1 in 10, across the globe [2]. Controlling individual cardiovascular complications has shown great efficiency in preventing mortality or slowing disease progression in people with diabetes [7]. Risk factors for T2DM and the related microvascular complications comprise a combination of both genetic and metabolic factors [8]. Given the recognition of diabetes as the global burden and the risk of CVDs with diabetes, the urgent need for early detection of T2DM and effective prediction of CVDs in T2DM seems to be emerging
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