Abstract
Background: Tremendous progress of imaging technique does not result in early diagnosis of gall bladder cancer. In search of effective, inexpensive and non-invasive tool tumour markers shows promise. Serum CA242, CA19.9 and CEA are evaluated for this purpose. Aim and objective: To evaluate diagnostic signicance of serum CA242, CA19.9 and CEAin gall bladder cancer either alone or in combination. Material and methods: It was an analytical cross sectional study done in Indira Gandhi Institute of medical Sciences. These markers were measured in 70 cases of gall bladder cancer and 70 healthycontrols. Serum CA242 was done by ELISA assay as per instruction given in pack insert (CD diagnostic). Serum CA19.9 and CEA were done by CLIA technique by Assess 2 analyser. Results: Mean value of these tumour marker were increased in gall bladder cancer group (p<0.001). CA19.9 was most sensitive tumourmarker (79.5%). Serum CA 242 was most specic test (83.3%) for diagnosis of gall bladder cancer among the three-tumour marker. On combination of tumour marker sensitivity (87.5%) and specicity (89.5%) were increased. In ROC curve analysis area under curve (AUC) for CA242 was highest. Conclusion: Combination of these tumour markers can be used as screening tool for gall bladder cancer.
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