Abstract
Purpose The significance of prostate specific antigen (PSA) in the mass screening for prostate cancer was investigated. Materials and Methods A total of 4,375 PSA, digital rectal and transrectal ultrasonographic examinations was performed on 3,526 subjects. Results Among the 3 modalities, PSA had the highest sensitivity (80.4 percent) and positive predictive value (45.1 percent). We established age-specific reference PSA ranges for normal Japanese men, and demonstrated the significance of PSA density and PSA velocity. Conclusions The significance of PSA as a prostate cancer screening modality should be evaluated across multiple age ranges and in combination with previous PSA data and/or prostate volume.
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