Diagnostic significance of esophageal high-resolution manometry in 233 patients with non-obstructive dysphagia

Abstract

Objective To explore the etiologies and characteristics of esophageal motility in patients with non-obstructive dysphagia by esophageal high-resolution manometry (HRM). Methods From November 2011 to August 2015, 233 patients with non-obstructive dysphagia diagnosed by HRM were retrospectively analyzed. All the patients received gastroendoscopy to exclude obstructive dysphagia. Results Among 233 patients with non-obstructive dysphagia, there were 160 cases of achalasia, 38 cases of nonspecific esophageal motor disorder (13 cases of low amplitude peristalsis or absent peristalsis, seven cases of synchronous contraction or rapid contraction, three cases of distal esophageal spasm, six cases of increased resting upper esophageal sphincter pressure (UESP), three cases of reduced UESP, six cases of lower esophageal sphincter (LES) incomplete relaxation), five cases of gastroesophageal reflux disease, four cases of scleroderma, two cases of Jackhammer esophagus, and 24 cases with normal esophageal motility. Conclusions Achalasia is the most common cause of non-obstructive dysphagia, followed by non-specific esophageal motor disorder. Esophageal HRM is an important method for the diagnosis of non-obstructive dysphagia, especially for unexplained dysphagia. Key words: High-resolution manometry, esophageal; Dysphagia; Esophageal motor disorder