Diagnostic Role of Serum Neutrophilic/Lymphocytic and Platelet/Lymphocytic Ratio in upper Gastrointestinal Lesions in Correlation with Histopathological Results of Endoscopic Ultrasonography and Upper Gastrointestinal Endoscopic Biopsies

Abstract

AbstractBackground: Systemic inflammatory markers including neutrophilic lymphocytic ratio and platelet lymphocytic ratio are used as prognostic and diagnostic factors to reflect the inflammatory process and tumor angiogenesis in many tumors including upper gastrointestinal submucosa tumors.Aim of Study: To determine the diagnostic efficacy of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in patients with uppergastrointestinal submucosal tumors.Patients and Methods: The present study included 30 patients with malignant and potentially malignant upper gastrointestinal submucosal tumor, 30 with benign upper gastrointestinal submucosal tumor and 30 healthy volunteers, complete blood counts with automated differential counts were performed. The NLR was calculated by dividing the absolute neutrophilic count by the absolute lymphocytic count while PLR was calculated by dividing the absolute platelet count by the absolute lymphocytic count. The diagnostic performance of NLR, PLR, was estimated by ROC curve.Results: ROC curve analysis showed high diagnostic efficacy of NLR and PLR in malignant and potentially malig-nant submucosal tumors patients with cut-off values of 2.25 (sensitivity=60%, and specificity=86.7, PPV 81.9%, NPV 68.4%) and 169 (sensitivity=93.3%, and specificity=100% PPV 100%, NPV 93.7%) compared to patients with benign lesions and healthy controls, respectively.Conclusion: NRL, PLR, may be useful markers in diag-nostic and early recognition of different upper gastrointestinal submucosal lesions.