Abstract
Background Meningiomas exhibit a wide range of histological appearances, and they may show overlapping morphology with other nonmeningothelial tumors, and so the differential diagnosis may be challenging.Aim To examine the diagnostic role of MUC4 expression in various histological subtypes and grades of meningioma and some other nonmeningothelial tumors relevant to the potential diagnosis.Materials and methods The expression of MUC4 and epithelial membrane antigen was analyzed by immunohistochemical staining in various subtypes of meningiomas and other nonmeningothelial tumors that enter in the differential diagnosis (schwannoma, solitary fibrous tumors/hemangiopericytoma, glioblastoma, and hemangioblastoma).Results A statistically significant difference was detected between MUC4 expression in meningioma and other nonmeningothelial tumors (P<0.001). MUC4 was expressed in 83.3% of meningioma cases and was entirely negative in nonmeningothelial tumors, with 83.3% sensitivity and 100% specificity.Conclusion MUC4 is a possible novel adjunct diagnostic marker that can distinguish between confusing cases of meningioma and the tested nonmeningothelial tumors.
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