Abstract
Sarcopenia is an age-associated disease characterized by loss of muscle mass and function, but the diagnostic cutoff values remain controversial. To investigate the diagnostic cutoff values and incidence of sarcopenia in a plateau population, the limb skeletal muscle mass, gait speed and grip strength of 2318 Tibetan adults were measured according to the criteria of the Asian Working Group for Sarcopenia. We found that the diagnostic reference values for sarcopenia in the high-altitude population were significantly lower than those in the plain population, and the incidences of sarcopenia in the high-altitude population over 60 years old were 17.2% in men and 36.0% in women, which were significantly higher than those in the plain population. Our study proposes reference values for the diagnosis of sarcopenia in Tibet. We suggest that the cutoff value for sarcopenia in the plateau population should be established based on altitude. Hypoxia may be an important risk factor for sarcopenia.
Highlights
Sarcopenia is an age-associated disease characterized by loss of muscle mass and function, but the diagnostic cutoff values remain controversial
Since 2010, the study of sarcopenia in the field of international geriatrics has become increasingly intense, focusing on the diagnostic criteria and pathogenesis of sarcopenia. Both the European and Asian sarcopenia working groups have recommended diagnostic criteria of sarcopenia based on muscle mass, muscle strength and physical function presented by skeletal muscle mass index (SMI), handgrip strength (HS) and gait speed (GS), respectively[4,5]
From this study (Table 2; Fig. 1), we found that limb skeletal muscle mass (LUSM), right upper limb skeletal muscle mass (RUSM), limb skeletal muscle mass (LLSM), right lower limb skeletal muscle mass (RLSM) and appendicular skeletal muscle (ASM) in Lhasa were greater than those in Shigatse at the same age and sex (P < 0.05)
Summary
Sarcopenia is an age-associated disease characterized by loss of muscle mass and function, but the diagnostic cutoff values remain controversial. To investigate the diagnostic cutoff values and incidence of sarcopenia in a plateau population, the limb skeletal muscle mass, gait speed and grip strength of 2318 Tibetan adults were measured according to the criteria of the Asian Working Group for Sarcopenia. Since 2010, the study of sarcopenia in the field of international geriatrics has become increasingly intense, focusing on the diagnostic criteria and pathogenesis of sarcopenia Both the European and Asian sarcopenia working groups have recommended diagnostic criteria of sarcopenia based on muscle mass, muscle strength and physical function presented by skeletal muscle mass index (SMI), handgrip strength (HS) and gait speed (GS), respectively[4,5]. We investigated the reference values of Tibetans living on the Qinghai-Xizang Plateau in China and provided cutoff value for the diagnosis of sarcopenia in the plateau population
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