Abstract
This lecture will focus on commonly encountered traps which may mislead pathologists when interpreting soft tissue lesions. These have been selected to reflect issues raised most frequently in consultation cases, based mainly on either over- or under-interpretation of morphological or immunohistochemical findings. Key themes include awareness of natural history (e.g., an inappropriate clinical context for a given diagnosis), benign lesions often mistaken for malignant (e.g., cellular benign fibrous histiocytoma, cellular schwannoma or lipomas with microscopic fat necrosis), malignant lesions easily mistaken as benign (e.g., low-grade fibromyxoid sarcoma and solitary fibrous tumour) and misinterpretation of immunohistochemical stains (e.g., use of needlessly broad panels, excessive antigen retrieval, mistaken assumptions regarding specificity and speculative but unvalidated use of biomarkers to distinguish benign from malignant).
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