Abstract

Purpose: Magnetic resonance imaging (MRI) transverse (spin-spin) relaxation time (T2) has been proposed as an imaging biomarker for detecting OA-related alterations in articular cartilage composition before the onset of radiographic knee OA (ROA). A recent meta-analysis reported cartilage T2 to significantly discriminate OA vs. controls, but these analyses have not demonstrated diagnostic sensitivity across pre-radiographic stages of early OA where T2 is thought to be most effective as an “early OA” marker.

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