Diagnostic Performance of Magnetic Resonance Imaging for Pediatric Ovarian Neoplasms: A Multi-Institutional Review

Abstract

Study ObjectiveTo assess diagnostic performance of MRI to predict ovarian malignancy alone and compared to other diagnostic studies. MethodsRetrospective analysis of patients aged 2 to 21 years who underwent ovarian mass resection between 2009-2021 at eleven pediatric hospitals. Sociodemographic information, clinical and imaging findings, tumor markers, and operative and pathology details were collected. Diagnostic performance for detecting malignancy was assessed by calculating sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for MRI with other diagnostic modalities. Results1,053 patients underwent resection of an ovarian mass with a median age of 14.6 years; 10% (110/1053) had malignant disease on pathology and 13% (136/1053) underwent preoperative MRI. MRI sensitivity, specificity, PPV, and NPV were 60%, 94%, 60%, 94%. Ultrasound sensitivity, specificity, PPV, and NPV were 31%, 99%, 73%, 95%. Tumor marker sensitivity, specificity, PPV, and NPV were 90%, 46%, 22%, 96%. MRI and ultrasound concordance was 88% with sensitivity, specificity, PPV, and NPV of 33%, 99%, 75%, 94%. MRI sensitivity in ultrasound-discordant cases was 100%. MRI and tumor marker concordance was 88% with sensitivity, specificity, PPV, and NPV of 100%, 86%, 64%, 100%. MRI specificity in tumor marker-discordant cases was 100%. ConclusionDiagnostic modalities used to assess ovarian neoplasms in pediatric patients typically agree. In cases of disagreement, MRI is more sensitive for malignancy than ultrasound and more specific than tumor markers. Selective use of MRI with preoperative ultrasound and tumor markers may be beneficial when the risk of malignancy is uncertain. Concise AbstractThis retrospective review of 1053 patients age 2-21 years who underwent ovarian mass resection between 2009-2021 at 11 pediatric hospitals found that ultrasound, tumor markers, and MRI tend to agree on benign vs malignant but in cases of disagreement, MRI is more sensitive for malignancy than US.