Diagnostic Paracentesis Within 1Day Is Associated With Reduced Mortality and Length of Hospital Stay in Patients with Cirrhosis and Ascites.

Abstract

Spontaneous bacterial peritonitis (SBP) is the most common infection in patients with cirrhosis and is associated with high mortality. Although recent literature reports mortality benefits to early diagnostic paracentesis, current guidelines do not offer specific recommendations for how quickly diagnostic paracentesis should be performed in patients with cirrhosis and ascites who are admitted to the hospital. Therefore, we conducted a systematic review and meta-analysis to evaluate outcomes among patients admitted to the hospital with cirrhosis and ascites receiving paracentesis within ≤ 12, ≤ 1day, and > 1day. Eight studies with 116,174 patients were included in the final meta-analysis. The pooled risk of in-hospital mortality was significantly lower in patients who underwent early (≤ 12h or ≤ 1day) compared to delayed (> 12h or > 1day) paracentesis (RR: 0.69, p < 0.00001), and in patients who underwent paracentesis compared to no paracentesis (RR: 0.74, p < 0.00001). On subgroup analysis, in-hospital mortality was significantly lower in both paracentesis within ≤ 12h (RR: 0.61, p = 0.02) vs. > 12h, and within ≤ 1day (RR: 0.70, p < 0.00001) vs. > 1day. While there was a trend towards decreased mortality in those undergoing paracentesis within ≤ 12h compared to ≤ 1day, the difference did not reach statistical significance. The length of hospital stay was significantly shorter by 5.38days in patients who underwent early (≤ 12h) compared to delayed (> 12h) paracentesis (95% CI 4.24-6.52, p < 0.00001). Early paracentesis is associated with reduced mortality and length of hospital stay. We encourage providers to perform diagnostic paracentesis in a timely manner, at least within 1day of hospital admission, for all patients with cirrhosis and ascites.