Abstract
Task-specific dystonia (TSD) is a challenging clinical diagnosis with no objective diagnostic biomarkers. The objective of this study was to test 2 neurophysiologic variables using transcranial magnetic stimulation as potential diagnostic biomarkers for TSD. We tested (1) cortical silent period (CSP) and (2) dorsal inferior parietal lobule-motor cortex (dIPL-M1) physiologic connectivity in 9 patients with the writer's cramp form of TSD and 12 healthy volunteers on 2 separate sessions. CSP was significantly prolonged (P< 0.0001) in TSD and could classify TSD with high sensitivity and specificity with areas under the receiver operating characteristic curve (AUCs)=0.94 and 0.90, respectively, for 2 separate sessions with an intraclass correlation=0.79. dIPL-M1 interaction was notable for significant motor cortical inhibition in TSD compared with facilitation in healthy subjects (P< 0.0001) and could classify TSD with high sensitivity and specificity with AUCs=0.96 and 0.86, respectively. CSP and dIPL-M1 physiologic connectivity can classify TSD with high sensitivity, specificity, reproducibility, and reliability.
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