Abstract
We used comprehensive serodiagnostic methods (IgM, IgG, and IgG avidity) and PCR to study Merkel cell polyomavirus and trichodysplasia spinulosa-associated polyomavirus infections in children observed from infancy to adolescence. Comparing seroconversion intervals with previous and subsequent intervals, we found that primary infections with these 2 viruses were asymptomatic in childhood.
Highlights
We used comprehensive serodiagnostic methods (IgM, IgG, and IgG avidity) and PCR to study Merkel cell polyomavirus and trichodysplasia spinulosaassociated polyomavirus infections in children observed from infancy to adolescence
Of the 45 children who seroconverted for MCPyV, 28 (62%) showed additional markers of primary infection at the time of IgG seroconversion: IgM was present in 15 (33%), and low avidity of IgG was detected in 23 (51%)
The seroprevalence of MCPyV and TSPyV among children
Summary
2011–July 2013 on a subset of a prospective study in which children were enrolled at birth and observed until young adolescence [8]. Before they were 1 year of age, 4 children showed IgG seroconversion for MCPyV at 0.68–0.94 year of age, 1 child showed seroconversion for TSPyV at 0.80 year, and another child showed MCPyV IgG, IgM, and low avidity of IgG in the first sample, which was collected at 0.63 year (online Technical Appendix Table 2) None of these children who Emerging Infectious Diseases www.cdc.gov/eid Vol 20, No 4, April 2014. Of the 45 children who seroconverted for MCPyV, 28 (62%) showed additional markers of primary infection at the time of IgG seroconversion: IgM was present in 15 (33%), and low avidity of IgG was detected in 23 (51%). To determine clinical correlates of MCPyV and TSPyV primary infections, all infection-related symptoms and illnesses during the seroconversion interval were compared with those during the previous or subsequent interval for each patient who seroconverted (Table).
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