Diagnostic laser light scattering spectroscopy for human eyes

Abstract

Using laser light scattering or photon correlation spectroscopy, changes in scattered light intensity fluctuations from the cornea and the lens of the in vivo human eye have been investigated. The fluctuations in light intensity result from Brownian motion of the scattering elements in the cornea and lens. Analysis of these signals provides information on the structure of these scatterers. Measurements have been made from a population of diabetics and non-diabetic subjects. Significant differences have been observed between diabetics and non-diabetics in both the cornea and the lens. This technique provides a quantitative, non-invasive method of clinical monitoring of ocular changes and offers the possibility of identifying those patients who may be at risk for clinical corneal complications or early cataract formation in the lens.Using laser light scattering or photon correlation spectroscopy, changes in scattered light intensity fluctuations from the cornea and the lens of the in vivo human eye have been investigated. The fluctuations in light intensity result from Brownian motion of the scattering elements in the cornea and lens. Analysis of these signals provides information on the structure of these scatterers. Measurements have been made from a population of diabetics and non-diabetic subjects. Significant differences have been observed between diabetics and non-diabetics in both the cornea and the lens. This technique provides a quantitative, non-invasive method of clinical monitoring of ocular changes and offers the possibility of identifying those patients who may be at risk for clinical corneal complications or early cataract formation in the lens.