Abstract
The aim of the present study was to evaluate the diagnostic significance of selected cellular and biochemical parameters in cerebrospinal fluid of sheep with listeriosis, coenurosis and oestrosis. A total of 25 ewes were examined, 10 with listeriosis, 5 with coenurosis, 5 with oestrosis, and 5 healthy. Cerebrospinal fluid (CPS) was collected from each ewe under investigation and examined for cellular and biochemical parameters. Polymorphonuclear cells differed significantly in listeria infected sheep than other infections (p < 0.05). However, a significant variation of total nucleated cell count and mononuclear cell among animal groups (P < 0.05). creatinine kinase, urea, crearinine and glucose ration differed significantly in listeria infected ewes when compared with coenurosis group. Malondialdehyde, superoxide dismutase, and catalase were significantly higher in coenurosis group in comparison with listeriosis group (p < 0.05). However, Reduced glutathione, nitric oxide, Lysozyme and nterleukin-1β were significantly decreased (p < 0.5). The results of the present study indicate that analysis of cerebrospinal fluid is important for diagnosis of neurological disorders in sheep.
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