Diagnostic Importance of Clinic-Pathologic Features and p16, CD34, MDM2 Expression in Differential Diagnosis of Tumors

Abstract

Background: The large majority of soft tissue tumors are benign. Malignant mesenchymal neoplasm amount toless than 1% of the overall human burden of malignant tumors but they are life threatening and may pose asignificant diagnostic and therapeutic challenge since there are more than 50 histological subtypes of STS, whichare often associated with unique clinical, prognostic and therapeutic features.Methods: The study was undertaken in department of Pathology, King George’s Medical University, Lucknow.The Study Design was Retrospective and prospective study carried over a period of two year from September2018 to august 2020 including 70 cases. Results. Most common diagnosis of malignant cases was Synovial saroma(21.4%) followed by Leiomyosarcoma (19.0%) and Undifferentiated pleomorphic sarcoma & Fibromyxoid sarcoma(11.9% each). Less common diagnosis were Ewing’s sarcoma, Liposarcoma and Rhabdomyosarcoma (9.5% each),1 (2.4%) case each was diagnosed as Chondrosarcoma, MPNST and Myxoid liposarcoma.Conclusions: Genetic alterations involving the 12q13-15 chromosomal region are common in musculoskeletalsarcomas, and many bone and soft-tissue malignant tumors showed amplification of various genes located in thisregion.