Abstract
Background & Objective:Early diagnosis can be made based on the morphological examination of bone marrow aspiration (BMA) until the bone marrow biopsy (BMB) result is reported. This allows for treatment to be started immediately, especially in hematological malignancies for which urgent treatment is indicated. This study aimed to determine the sensitivity and importance of bone marrow aspiration in the diagnosis of hematological malignancies.Methods:In this study, the data of patients who underwent bone marrow aspiration and bone marrow biopsy in Van Yuzuncu Yil University hospital between 2017 and 2019 were retrospectively analyzed. A total of 500 patients who simultaneously underwent BMA and BMB were included in the study. Data were obtained from electronic medical records.Results:Indication for bone marrow evaluation was abnormalities in complete blood count in 270 (54%) of patients. The diagnosis was made based on the evaluation of BMA in 475 (95%). In 456 (96%) of the 475 patients diagnosed with BMA, the diagnosis was consistent with that of BMB. Agreement of BMB with BMA was 100% in acute and chronic leukemias, while BMA was not sufficient for the diagnosis of lymphoma and solid organ metastasis.Conclusion:Our study showed that the evaluation of BMA was highly sensitive in the diagnosis of hematological malignancies, such as acute leukemias, chronic leukemias, and multiple myeloma.
Highlights
The morphological examination of bone marrow aspiration (BMA) offers an accurate and early diagnosis of some hematological malignancies within a few hours until the result of bone marrow biopsy (BMB) is reported within an average of 10-14 days
Table-II presents the results of the BMA evaluations in all the patients
Among the 475 patients diagnosed based on the BMA evaluation, the diagnosis was consistent with the BMB report in 456 (96%) cases (Table-III)
Summary
As a large organ mass, bone marrow is the source of many hematological diseases and a site of involvement of some infections, solid organ metastases, and metabolic diseases.[1]. The examination of bone marrow in many blood diseases is an important diagnostic tool following the assessment of medical history, physical examination, blood count analysis, and examination of peripheral smear morphology. In such cases, it is of great importance to examine using bone marrow aspiration and bone marrow biopsy procedures, which are usually, performed simultaneously.[2]. Diagnosis can be made based on the morphological examination of bone marrow aspiration (BMA) until the bone marrow biopsy (BMB) result is reported. This allows for treatment to be started immediately, especially in hematological malignancies for which urgent treatment is indicated. Conclusion: Our study showed that the evaluation of BMA was highly sensitive in the diagnosis of hematological malignancies, such as acute leukemias, chronic leukemias, and multiple myeloma
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