Abstract
The unfavorable application-to-tumor-dose-ratio is a drawback of conventional systemic chemotherapy, implying an often insufficient drug dose in the tumor being associated with severe side effects for the patient. The use of chemotherapeutics bound to magnetic nanoparticles offers several advantages. On the one hand it is possible to concentrate the chemotherapeutics in the tumor region by the use of magnetic fields, like it is done in Magnetic Drug Targeting (MDT). On the other hand magnetic particles can serve as contrast agent for magnetic resonance imaging (MRI) that is bound to the therapeutics. Hence, the particles possibly are opening an insight into drug distribution in the tumor region directly after administration.Another important factor for a successful MDT-application is detailed knowledge about tumor vascularization.In this pilot study we investigated vascularization and size of an tumor in an experimental in vivo tumor model via flat-panel angiography and DYNA-CT before MDT and the particle distribution with MRI after MDT.We could show that the tumor could be displayed by MRI and DYNA-CT before and after MDT. Flat panel angiography revealed clearly the pathological tumor vascularization before MDT, while MRI imaging afterwards displayed the tumor as well as the particle distribution in the tumor.
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