DIAGNOSTIC FEATURES OF DYSFUNCTION IN CYTOKINE AND SYMPATHOADRENAL SYSTEMS WITH ISCHEMIC STROKE

Abstract

The aim: Was a comprehensive study of the changes in features like structural and functional parameters of brain tissue, cytokine profile and β-adrenoceptor in the acute period of ischemic stroke (IS) to optimise diagnosis and treatment. The study was conducted at the Department of Neurosurgery and Neurology at the Medical Institute of Sumy State University. Materials and methods: Measurements of complex dielectric constant (CDC) were performed by EHF dielectrometry. Determination of plasma levels of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) was performed by solid-phase enzyme-linked immunosorbent assay. The work was based on the materials of a comprehensive examination of 350 patients with the first in the life of IS on the 1st, 10th and 21st day of the disease. Results: Cerebral hypoxia leads to a significant increase in the CDC of erythrocyte membranes (about 15 %), which may lead to a rise in the volume fraction of water in cell suspensions due to damage of their membrane-receptor complex (MRC). The revealed connections between changes of CDC of patients with IS and decrease insensitivity of their MRC to adrenergic drugs testify in favour of damaging action of hypoxia. An imbalance in the cytokine system and their relationship to the sympathoadrenal system has been identified. Conclusions: There is a strong association of mechanisms that damage the MRC of cells during acute cerebral ischemia with functional changes in both the sympathoadrenal and cytokine systems. Identified links in the pathogenesis of IS should be used for early diagnosis of the disease.